Background: Hemangioma is one of the umbilical cord anomalies and it is arising from the remnants of embryo hemangioblasts. It is associated with increased perinatal morbidity and mortality.
Case report: We describe an umbilical cord hemangioma that was identified in antenatal period. The patient was referred to our hospital for further evaluation of omphalocele that was noticed at gestational age of 29 week. The mass, measured 80*75*50 mm diameter, was surrounded by edema of the Wharton jelly. Color Doppler imaging revealed arterial and venous flow within the mass. The neoplasm was composed of organized and non-organized capillary vessels within the myxoid stroma. Neoplasm was covered with squamous epithelium focally but the epithelium was widely eroded. The immunohistochemical examination positive staining was obtained for vimentin, desmin, CD34 and SMA.
Conclusion: Umbilical cord anomalies are rare. Early detection and close follow-up can reduce the risk of perinatal morbidity and mortality.
(1) Browne EJ. On the abnormalities of the umbilical cord which may cause antenatal death. J Obstet Gynecol Br Commonw. 1925;32:11–48.
(2) Daniel-Spiegel E, Weiner E, Gimburg G, Shalev E. The association of umbilical cord hemangioma with fetal vascular birthmarks. Prenat Diagn. 2005;25(4):300-303. doi:10.1002/pd.1109
(3) Yan J, Zhu Y, Liao H, Su L, Guo Y, Cai J. A case of umbilical cord hemangioma. Rom J Leg Med. 2014;22:177-80. doi:10.4323/rjlm.2014.177
(4) Iglesias-Deus A, Pérez-Muñuzuri A, Urisarri A, Bautista-Casasnovas A, Couce ML. Umbilical cord and visceral hemangiomas diagnosed in the neonatal period: A case report and a review of the literature. Medicine (Baltimore). 2016;95(42):e5196. doi:10.1097/MD.0000000000005196
(5) Iyoob SD, Tsai A, Ruchelli ED, Coleman BG, Wilson RD. Large umbilical cord hemangioma: sonographic features with surgical pathologic correlation. J Ultrasound Med. 2006;25(11):1495-1498. doi:10.7863/jum.2006.25.11.1495
(6) Matsuda S, Sato Y, Marutsuka K, et al. Hemangioma of the umbilical cord with pseudocyst. Fetal Pediatr Pathol. 2011;30(1):16-21. doi:10.3109/15513811003796920
(7) Sathiyathasan S, Jeyanthan K, Hamid R. Umbilical hemangioma: a case report. Arch Gynecol Obstet. 2011;283 Suppl 1:15-17. doi:10.1007/s00404-010-1606-y
(8) Adams KV, Bernieh A, Morris RW, Saad AG. Umbilical Cord Teratomas Associated With Congenital Malformations. Arch Pathol Lab Med. 2020;144(2):156-159. doi:10.5858/arpa.2019-0161-RA
(9) Angelico G, Spadola S, Ieni A, Gurrera A, Arena MG, Vitale SG, et al. Hemangioma of the umbilical cord with associated amnionic inclusion cyst: two uncommon entities occurring simultaneously. Pathologica. 2019;111(1):13-17. doi:10.32074/1591-951X-26-17
(10) Papadopoulos VG, Kourea HP, Adonakis GL, Decavalas GO. A case of umbilical cord hemangioma: Doppler studies and review of the literature. Eur J Obstet Gynecol Reprod Biol. 2009;144(1):8-14. doi:10.1016/j.ejogrb.2009.01.011
(11) Armes JE, Billson VR. Umbilical cord hemangioma associated with polyhydramnios, congenital abnormalities and perinatal death in a twin pregnancy. Pathology. 1994;26(2):218-220. doi:10.1080/00313029400169521
(12) Abdalla N, Bachanek M, Trojanowski S, Cendrowski K, Sawicki W. Placental tumor (chorioangioma) as a cause of polyhydramnios: a case report. Int J Womens Health. 2014;6:955-959. Published 2014 Nov 20. doi:10.2147/IJWH.S72178
(13) Søndergaard G. Hemangioma of the umbilical cord. Acta Obstet Gynecol Scand. 1994;73(5):434-436.
(14) Dombrowski MP, Budev H, Wolfe HM, Sokol RJ, Perrin E. Fetal hemorrhage from umbilical cord hemangioma. Obstet Gynecol. 1987;70(3 Pt 2):439-442.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 2023 Betül Yakıştıran, Şevki Çelen, Ayşegül Aksakal Uslu