Keywords
inflammation
premature membrane rupture
pregnancy
How to Cite
Abstract
Objective: Preterm premature rupture of membranes (PPROM) is rupture of membranes before 37 weeks of gestation. It is the most common cause associated with preterm labor, accounting for about one-third of preterm births. Osteopontin is a phosphorylated and glycosylated protein consisted of 264-301 amino acids. It is an extracellular matrix member. It has been observed in various biological fluids, epithelial cells, gastrointestinal system secretions, kidneys, thyroid, breast, uterus, placenta and testis. The aim of this study was to investigate whether there is a significant relationship between maternal serum osteopontin levels and PPROM. Also, this study aimed to evaluate the role of osteopontin in the prediction and appropriate management of PPROM.
Materials and Methods: This prospective cross-sectional study was conducted in the Gynecology and Obstetrics Clinic of Dr. Sami Ulus Obstetrics, Gynecology and Pediatrics Training and Research Hospital. The study group consisted of pregnant women who were hospitalized due to PPROM and the control group consisted of healthy pregnant women who were followed up in outpatient clinic. For biochemical analysis, fifteen milliliters venous blood samples were taken from all participants. Plasma Osteopontin and CRP values, and sedimentation rate were measured.
Results: A total of 64 pregnant women, 32 patients in each group, were included. Serum leukocyte, sedimentation, C reactive protein and osteopontin levels of pregnant women in the control group were significantly lower than those of participants in the PPROM group.
Conclusions: Serum Osteopontin levels increase in patients diagnosed with PPROM. Measuring serum Osteopontin levels may be used as an important marker in the prediction and management of PPROM.
References
(1) Garg A, Jaiswal A. Evaluation and Management of Premature Rupture of Membranes: A Review Article. Cureus. 2023;15(3):e36615.
(2) Menon R, Richardson LS. Preterm prelabor rupture of the membranes: a disease of the fetal membranes. Semin Perinatol. 2017;41:409–419.
(3) Mercer BM. Preterm premature rupture of the membranes: current approaches to evaluation and management. Obstet Gynecol Clin North Am. 2005;32:411–428.
(4) Kwon HK, Choi GB, Huh JR. Maternal inflammation and its ramifications on fetal neurodevelopment. Trends Immunol. 2022;43(3):230-244.
(5) Sodek J, Ganss B, McKee MD. Osteopontin. Crit Rev Oral Biol Med. 2000;11(3):279-303.
(6) Denhardt DT, Noda M, O'Regan AW, Pavlin D, Berman JS. Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival. J Clin Invest. 2001;107(9):1055-1061.
(7) Johnson GA, Burghardt RC, Joyce MM, et al. Osteopontin is synthesized by uterine glands and a 45-kDa cleavage fragment is localized at the uterine-placental interface throughout ovine pregnancy. Biology of Reproduction. 2003;69(1):92-98.
(8) e QT, Sutphin PD, Raychaudhuri S, Yu SC, Terris DJ, Lin HS, Lum B, Pinto HA, Koong AC, Giaccia AJ: Identification of osteopontin asa prognostic plasma marker for head and neck squamouscell carcinomas. Clin Cancer Res. 2003, 9:59-67.
(9) Stepan M, Cobo T, Musilova I, et al. Maternal Serum C-Reactive Protein in Women with Preterm Prelabor Rupture of Membranes. PLoS One. 2016;11(3):e0150217.
(10) Balciuniene G, Kvederaite-Budre G, Gulbiniene V, et al. Neutrophil-lymphocyte ratio for the prediction of histological chorioamnionitis in cases of preterm premature rupture of membranes: a case-control study. BMC Pregnancy Childbirth. 2021;21(1):656.
(11) Amirabi A, Naji S, Yekta Z, Sadeghi Y. Chorioamnionitis and diagnostic value of C-reactive protein, erythrocyte sedimentation rate and white blood cell count in its diagnosis among pregnant women with premature rupture of membranes. Pak J Biol Sci. 2012;15(9):454-458.
(12) Lund SA, Giachelli CM, Scatena M. The role of osteopontin in inflammatory processes. J Cell Commun Signal. 2009;3(3-4):311-22.
(13) Johnson GA, Burghardt RC, Bazer FW, Spencer TE. Osteopontin: roles in implantation and placentation. Biol Reprod. 2003;69(5):1458-1471.
(14) Liu N, Zhou C, Chen Y, Zhao J. The involvement of osteopontin and β3 integrin in implantation and endometrial receptivity in an early mouse pregnancy model. Eur J Obstet Gynecol Reprod Biol. 2013;170(1):171-176.
(15) Qu X, Yang M, Zhang W, et al. Osteopontin expression in human decidua is associated with decidual natural killer cells recruitment and regulated by progesterone. In Vivo. 2008;22(1):55-61.
(16) Winhofer Y, Kiefer FW, Handisurya A, Tura A, Klein K, Schneider B, Marculescu R, Wagner OF, Pacini G, Luger A, Stulnig TM, Kautzky-Willer A. CTX (crosslaps) rather than osteopontin is associated with disturbed glucose metabolism in gestational diabetes. PLoS One. 2012;7(7):e40947.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 2024 Ozlem Gunduz, Tuncay Kucukozkan